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P-Cresyl sulfate

CAT: 0804-HY-111431-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111431-01Size:5 mg
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Description
P-Cresyl sulfate (p-Tolyl sulfate) is a uremic toxin, that can cause renal damage and dysfunction. p-Cresyl sulfate shows antiproliferation activity. p-Cresyl sulfate increases the protein expression of HIF-1α and VHL, decreases the protein expression of HIF-2α. p-Cresyl sulfate induces epithelial-mesenchymal transition (EMT) . p-Cresyl sulfate activates the JNK and p38 MAPK signaling pathways[1][2][3].
CAS Number
3233-58-7
Product Name Alternative
P-Tolyl sulfate
UNSPSC
12352005
Hazard Statement
H302, H314, H335
Target
JNK; p38 MAPK; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/p-Cresyl_Sulfate.html
Concentration
10mM
Purity
99.98
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
O=S(OC1=CC=C(C)C=C1)(O)=O
Molecular Formula
C7H8O4S
Molecular Weight
188.20
Precautions
H302, H314, H335
References & Citations
[1]Wu TK, et al. The uremic toxin p-cresyl sulfate induces proliferation and migration of clear cell renal cell carcinoma via microRNA-21/ HIF-1α axis signals. Sci Rep. 2019 Mar 1;9 (1) :3207.|[2]Koppe L, et al. p-Cresyl sulfate promotes insulin resistance associated with CKD. J Am Soc Nephrol. 2013 Jan;24 (1) :88-99.|[3]Tanaka H, et al. p-Cresyl sulfate induces osteoblast dysfunction through activating JNK and p38 MAPK pathways. Bone. 2013 Oct;56 (2) :347-54.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; Microbial Metabolite
Citation 01
Cell Death Dis. 2023 Feb 2;14 (2) :78.|Phytomedicine. 2024 Oct 28:135:156174.|ACS Appl Bio Mater. 2024 Jun 17;7 (6) :3841-3853.|Cell Metab. 2024 Jun 18:S1550-4131 (24) 00189-X.|Colloids Surf B Biointerfaces. 2024 Aug 13:244:114164.|Electrochim Acta. 2025 Oct 26.

Chemical Information

P-Cresol sulfate

P-cresol sulfate is an aryl sulfate that is p-cresol in which the phenolic hydrogen has been replaced by a sulfo group. It has a role as a uremic toxin, a human metabolite and a gut flora metabolite. It is functionally related to a p-cresol. It is a conjugate acid of a p-cresol sulfate(1-).

CAS Number3233-58-7
PubChem CID4615423
IUPAC Name(4-methylphenyl) hydrogen sulfate
Molecular FormulaC7H8O4S
Molecular Weight188.20
XLogP1.3
Topological Polar Surface Area72
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count12
Formal Charge0
Complexity220
SMILES
CC1=CC=C(C=C1)OS(=O)(=O)O
InChI
InChI=1S/C7H8O4S/c1-6-2-4-7(5-3-6)11-12(8,9)10/h2-5H,1H3,(H,8,9,10)
InChIKey
WGNAKZGUSRVWRH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of P-Cresol sulfate
CAS: 3233-58-7
CID: 4615423
Formula: C7H8O4S
MW: 188.20
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight188.20
XLogP31.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass188.01432991
Monoisotopic Mass188.01432991
Topological Polar Surface Area72 Ų
Heavy Atom Count12
Formal Charge0
Complexity220
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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