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Isatin (Standard)

CAT: 0804-HY-Y0265R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-Y0265R-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Isatin (Standard) is the analytical standard of Isatin. This product is intended for research and analytical applications. Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM) [1]. Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity[2]. Shows effect on the serotonergic system[3].
CAS Number
91-56-5
Product Name Alternative
Indoline-2,3-dione (Standard)
UNSPSC
12352005
Target
Apoptosis; Monoamine Oxidase; Reference Standards
Type
Reference compound
Related Pathways
Apoptosis; Neuronal Signaling; Others
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/isatin-standard.html
Smiles
O=C1NC2=C(C=CC=C2)C1=O
Molecular Formula
C8H5NO2
Molecular Weight
147.13
References & Citations
[1]Glover V, et al. Isatin: Identity with the Purified Endogenous Monoamine Oxidase Inhibitor Tribulin. Journal of Neurochemistry, 51 (2), 656–659.|[2]Igosheva N, et al. Isatin, an endogenous monoamine oxidase inhibitor, triggers a dose- and time-dependent switch from apoptosis to necrosis in human neuroblastoma cells. Neurochem Int. 2005 Aug;47 (3) :216-24.|[3]McIntyre IM, et al. Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin. J Neural Transm Gen Sect. 1990;79 (1-2) :35-40.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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