Isatin

• Description :

  Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM) [1]. Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity[2]. Shows effect on the serotonergic system[3].

• Product Name Alternative :

  Indoline-2,3-dione

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis; Monoamine Oxidase

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Neuronal Signaling

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Neurological Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/Isatin.html

• Purity :

  99.93

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)

• Smiles :

  O=C1NC2=C(C=CC=C2)C1=O

• Molecular Formula :

  C8H5NO2

• Molecular Weight :

  147.13

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Glover V, et al. Isatin: Identity with the Purified Endogenous Monoamine Oxidase Inhibitor Tribulin. Journal of Neurochemistry, 51 (2), 656–659.|[2]Igosheva N, et al. Isatin, an endogenous monoamine oxidase inhibitor, triggers a dose- and time-dependent switch from apoptosis to necrosis in human neuroblastoma cells. Neurochem Int. 2005 Aug;47 (3) :216-24.|[3]McIntyre IM, et al. Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin. J Neural Transm Gen Sect. 1990;79 (1-2) :35-40.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [91-56-5]