Isatin

Isatin

• CAS Number: 91-56-5
• UNSPSC Description: Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM)[1]. Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity[2]. Shows effect on the serotonergic system[3].
• Target Antigen: Apoptosis; Monoamine Oxidase
• Type: Natural Products
• Related Pathways: Apoptosis;Neuronal Signaling
• Applications: Cancer-programmed cell death
• Field of Research: Cancer; Neurological Disease; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/Isatin.html
• Purity: 99.93
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic)
• Smiles: O=C1NC2=C(C=CC=C2)C1=O
• Molecular Weight: 147.133
• References & Citations: [1]Glover V, et al. Isatin: Identity with the Purified Endogenous Monoamine Oxidase Inhibitor Tribulin. Journal of Neurochemistry, 51(2), 656–659.|[2]Igosheva N, et al. Isatin, an endogenous monoamine oxidase inhibitor, triggers a dose- and time-dependent switch from apoptosis to necrosis in human neuroblastoma cells. Neurochem Int. 2005 Aug;47(3):216-24.|[3]McIntyre IM, et al. Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin. J Neural Transm Gen Sect. 1990;79(1-2):35-40.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported