Isatin

CAT: 0804-HY-Y0265-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-Y0265-01Size:500 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM) [1]. Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity[2]. Shows effect on the serotonergic system[3].
CAS Number
[91-56-5]
Product Name Alternative
Indoline-2,3-dione
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Monoamine Oxidase
Type
Natural Products
Related Pathways
Apoptosis; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Isatin.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
O=C1NC2=C(C=CC=C2)C1=O
Molecular Formula
C8H5NO2
Molecular Weight
147.13
Precautions
H302, H315, H319, H335
References & Citations
[1]Glover V, et al. Isatin: Identity with the Purified Endogenous Monoamine Oxidase Inhibitor Tribulin. Journal of Neurochemistry, 51 (2), 656–659.|[2]Igosheva N, et al. Isatin, an endogenous monoamine oxidase inhibitor, triggers a dose- and time-dependent switch from apoptosis to necrosis in human neuroblastoma cells. Neurochem Int. 2005 Aug;47 (3) :216-24.|[3]McIntyre IM, et al. Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin. J Neural Transm Gen Sect. 1990;79 (1-2) :35-40.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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