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E28362

CAT: 0804-HY-162562-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-162562-01Size:5 mg
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Description
E28362 is a novel small molecule PCSK9 inhibitor. E28362 blocks the interaction between PCSK9 and LDLR, thereby preventing the degradation of LDLR and maintaining cholesterol homeostasia. E28362 is a promising lead compound for the study of hyperlipidemia and atherosclerosis[1].
CAS Number
930017-01-9
UNSPSC
12352005
Target
PCSK9
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/e28362.html
Purity
94.51
Smiles
O=C1NC(CN(CC(O)C)C2=O)=C2C(C3=CC=C(C)C=C3)N1
Molecular Formula
C16H19N3O3
Molecular Weight
301.34
References & Citations
[1]Wang W, et al. A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis[J]. Acta Pharmacologica Sinica, 2024: 1-15.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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