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Alpha-2-Macroglobulin Antibody / A2M

CAT: 0013-GTR18318101Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18318101Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Alpha-2-Macroglobulin (Alpha-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, Alpha-2M was characterized as a pan-proteinase inhibitor that was able to bait proteinases into cleaving specific peptide sequences on Alpha-2M. This interaction induces a conformational change in Alpha-2M, thus enabling it to trap the proteinase and further inhibit its activity. Subsequently, Alpha-2M has been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor beta (TGFbeta) in serum is primarily bound to Alpha-2M, which renders TGFbeta inactive. Alpha-2M also binds to IL-6 and, thereby, increases the concentration of IL-6 near lymphocytes, hepatocytes and stem cells involved in mediating the inflammatory cascade. Mutations and deletions in the gene encoding Alpha-2M are associated with an increased incidence of Alzheimer s disease (AD), which is consistent with the role of Alpha-2M in mediating the clearance and degradation of A beta, the major component of beta-Amyloid deposits accumulated during AD.
UniProt
P01023
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 600-900) from the human protein was used as the immunogen for the Alpha-2-Macroglobulin antibody.
Clonality
Monoclonal
Clone
A2M/4848
Conjugation
Unconjugated
Purification
Protein A/G affinity
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the Alpha-2-Macroglobulin antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG

UniProtKB · P01023

Alpha-2-macroglobulin

A2MG_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01023
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
A2M
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Alpha-2-M
EC number
—
Processing
Precursor
Secondary accessions
Q13677, Q59F47, Q5QTS0, Q68DN2, Q6PIY3, Q6PN97
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Domain

Bait regionSignal

PTM

Disulfide bondGlycoproteinIsopeptide bondThioester bond

Molecular function

Protease inhibitorSerine protease inhibitor

Cellular component

Secreted

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