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TGF beta 2 Antibody / TGFB2

CAT: 0013-GTR18317020Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18317020Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Transforming growth factor Bs (TGFbs) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGFa. It is now realized that TGFbs mediate many cell-cell interactions that occur during embryonic development. Three TGFbs have been identified in mammals. TGFb1, TGFb2 and TGFb3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFb requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFb3 protein has approximately 80% identity to the mature region of both TGFb1 and TGFb2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity.
UniProt
P10600
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the TGF beta 2 antibody.
Clonality
Monoclonal
Clone
TGFB2/1679
Conjugation
Unconjugated
Purification
Protein A/G affinity
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the TGF beta 2 antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG1, kappa

UniProtKB · P10600

Transforming growth factor beta-3 proprotein

TGFB3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P10600
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TGFB3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q8WV88
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

CardiomyopathyDisease variant

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinMethylation

Cellular component

Extracellular matrixSecreted

Molecular function

Growth factorMitogen

Domain

Signal

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