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OCLN Antibody / Occludin

CAT: 0013-GTR18316745-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18316745-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of Occludin. Expression of Occludin is upregulated by polyunsaturated fatty acids, increasing trans-endothelial cell resistance and reducing cellular permeability to large molecules. The level of Occludin varies greatly depending on tissue; in brain tissue, Occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Up-regulation of epithelial Occludin may play a role in enhancing paracellular permeability and be related to the damage to the tight junction.
UniProt
Q16625
Reactivity
Human
Immunogen
A recombinant human protein fragment (within amino acids 282-415) was used as the immunogen for the OCLN antibody.
Clonality
Recombinant
Clone
ROCLN/8525
Conjugation
Unconjugated
Field of Research
Signal Transduction
Purification
Protein A/G affinity
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT, Western blot: 2-4ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the OCLN antibody should be determined by the researcher.
Tested Applications
IHC-P, WB
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide
Isotype
Mouse IgG1, kappa

UniProtKB · Q16625

Occludin

OCLN_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q16625
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
OCLN
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B5BU70, D2DU64, D2DU65, D2IGC0, D2IGC1, E2CYV9, Q5U1V4, Q8N6K1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell junctionCell membraneMembraneTight junction

Domain

Coiled coilTransmembraneTransmembrane helix

Disease

Disease variant

PTM

Disulfide bondPhosphoprotein

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