Calcium 2-oxoglutarate

• UNSPSC Description:

  Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of tyrosinase (IC50=15 mM)[1][2].

• Target Antigen:

  Endogenous Metabolite; Tyrosinase

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/calcium-2-oxoglutarate.html

• Purity:

  98.0

• Solubility:

  H2O : 4.85 mg/mL (ultrasonic;warming;adjust pH to 4 with HCl;heat to 60°C)

• Smiles:

  O=C([O-])C(CCC([O-])=O)=O.[Ca+2]

• Molecular Weight:

  184.16

• References & Citations:

  [1]Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35.|[2]Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105(Pt 3):1654-1662.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  No Development Reported

• CAS Number:

  71686-01-6