Mupirocin (calcium)

CAT: 0804-HY-B0958ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-B0958ASize:1 Each
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Description
Mupirocin (BRL-4910A, Pseudomonic acid) calcium is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin calcium apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis[1][2].
CAS Number
[104486-81-9]
Product Name Alternative
BRL-4910A (calcium) ; Pseudomonic acid (calcium)
UNSPSC
12352005
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mupirocin-calcium.html
Solubility
10 mM in DMSO
Smiles
O[C@@H]([C@H]([C@H](C/C(C)=C/C(OCCCCCCCCC(O)=O)=O)OC1)O)[C@@]1([H])C[C@H]2[C@@]([C@@H](C)[C@@H](O)C)([H])O2.[1/2].[Ca]
Molecular Formula
C26H44O9.1/2Ca
Molecular Weight
520.66
References & Citations
[1]Sutherland R, et al. Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use. Antimicrob Agents Chemother. 1985 Apr;27 (4) :495-8.|[2]Parenti MA, et al. Mupirocin: a topical antibiotic with a unique structure and mechanism of action. Clin Pharm. 1987 Oct;6 (10) :761-70.|[3]Vingsbo Lundberg C, et al. Efficacy of topical and systemic antibiotic treatment of meticillin-resistant Staphylococcus aureus in a murine superficial skin wound infection model. Int J Antimicrob Agents. 2013 Sep. 42 (3) :272-5.|[4]Mohammad H, Abutaleb NS, Dieterly AM, Lyle LT, Seleem MN. Investigating auranofin for the treatment of infected diabetic pressure ulcers in mice and dermal toxicity in pigs. Sci Rep. 2021 May 25;11 (1) :10935.|[5]Giacometti A, et al. Mupirocin prophylaxis against methicillin-susceptible, methicillin-resistant, or vancomycin-intermediate Staphylococcus epidermidis vascular-graft infection. Antimicrob Agents Chemother. 2000 Oct. 44 (10) :2842-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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