C-178

C-178

• CAS Number: 329198-87-0
• UNSPSC Description: C-178 is a potent and selective covalent inhibitor of STING. C-178 binds to Cys91 and suppresses the STING responses elicited by distinct bona fide activators in mouse but not human[1].
• Target Antigen: STING
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/sting-inhibitor-c-178.html
• Purity: 99.04
• Solubility: DMSO : 41.67 mg/mL (ultrasonic)
• Smiles: O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C3C(OC4=CC=CC=C34)=C2
• Molecular Weight: 322.27
• References & Citations: [1]Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported