C-178

• Description :

  C-178 is a potent and selective covalent inhibitor of STING. C-178 binds to Cys91 and suppresses the STING responses elicited by distinct bona fide activators in mouse but not human[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  STING

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/sting-inhibitor-c-178.html

• Purity :

  99.48

• Solubility :

  DMSO : 41.67 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C3C(OC4=CC=CC=C34)=C2

• Molecular Formula :

  C17H10N2O5

• Molecular Weight :

  322.27

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559 (7713) :269-273.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [329198-87-0]