Palmitoleoyl-CoA (lithium)

• UNSPSC Description:

  Palmitoleoyl-CoA lithium is the lithium salt form of Palmitoleoyl-CoA (HY-137782). Palmitoleoyl-CoA lithium can be activated and transported into the mitochondria for metabolism, specifically for β-oxidation. Palmitoleoyl-CoA lithium induces the cardiac mitochondrial membrane permeability transition, which causes mitochondrial dysfunction. Palmitoleoyl-CoA lithium regulates metabolism via allosteric control of AMPK β1-isoforms[1][2].

• Target Antigen:

  Biochemical Assay Reagents

• Type:

  Enzyme

• Related Pathways:

  Others

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/palmitoleoyl-coa-lithium.html

• Smiles:

  O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(OP(O)(OCC(C)([C@H](C(NCCC(NCCSC(CCCCCCC/C=C\CCCCCC)=O)=O)=O)O)C)=O)=O)O[C@H]1N2C3=NC=NC(N)=C3N=C2.[Li].[x]

• References & Citations:

  [1]Oyanagi E, et al., Palmitoleic acid induces the cardiac mitochondrial membrane permeability transition despite the presence of L-carnitine. Biochem Biophys Res Commun. 2015 Jul 17-24;463(1-2):29-36.|[2]Stephen L Pinkosky, et al. Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms. Nat Metab. 2020 Sep;2(9):873-881.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  324518-22-1