Ethylenediaminetetraacetic acid

Ethylenediaminetetraacetic acid

• CAS Number: 60-00-4
• UNSPSC Description: Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research[1][2][3][4][5][6][7].
• Target Antigen: Bacterial; Biochemical Assay Reagents; SOD
• Type: Biochemical Assay Reagents
• Related Pathways: Anti-infection;Immunology/Inflammation;Others
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Neurological Disease; Cardiovascular Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/ethylenediaminetetraacetic-acid.html
• Purity: 98.0
• Solubility: 0.1 M NaOH : 6.67 mg/mL (ultrasonic;warming;adjust pH to 7 with NaOH;heat to 60°C)|1M NaOH : 25 mg/mL (ultrasonic)
• Smiles: O=C(O)CN(CCN(CC(O)=O)CC(O)=O)CC(O)=O
• Molecular Weight: 292.24
• References & Citations: [1]Chumanov RS, et al. Artifact-inducing enrichment of ethylenediaminetetraacetic acid and ethyleneglycoltetraacetic acid on anion exchange resins. Anal Biochem. 2011 May 1;412(1):34-9. |[2]Banfi G, et al. The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes. Clin Chem Lab Med. 2007;45(5):565-76. |[3]Ibad A, et al. Chelation therapy in the treatment of cardiovascular diseases. J Clin Lipidol. 2016 Jan-Feb;10(1):58-62. |[4]Gray GW, et al. The effect of ethylenediaminetetra-acetic acid on the cell walls of some gram-negative bacteria. J Gen Microbiol. 1965 Jun;39(3):385-99. |[5]González-Cuevas J, et al. Ethylenediaminetetraacetic acid induces antioxidant and anti-inflammatory activities in experimental liver fibrosis. Redox Rep. 2011;16(2):62-70. |[6]Naghipour D, et al. Remediation of heavy metals contaminated silty clay loam soil by column extraction with ethylenediaminetetraacetic acid and nitrilo triacetic acid[J]. Journal of Environmental Engineering, 2017, 143(8): 04017026.|[7] Deai M, et al. Ethylenediaminetetraacetic acid (EDTA) enhances cAMP production in human TDAG8-expressing cells. Biochem Biophys Res Commun. 2022 Oct 20;626:15-20. Adv Sci (Weinh). 2022 Dec 12;e2204998.|bioRxiv. 2023 Sep 8.|Cell Immunol. 2023 Nov 2, 104781.|Colloids Surf B Biointerfaces. 2023 Dec 2, 113680.|Int J Biol Macromol. 2022.|Molecules. 2024 Jul 30;29(15):3590.|Nucleic Acids Res. 2024 Nov 30:gkae1112.|Biomed Pharmacother. 2019 Jan;109:2427-2433. |Molecules. 2021 Aug 24;26(17):5115.|Research Square Preprint. 2021 Oct.|Environ Sci Technol. 2017 Dec 5;51(23):13938-13948.
• Shipping Conditions: Room Temperature
• Storage Conditions: RT, protect from light, stored under nitrogen
• Clinical Information: Launched