Products for Research Use Only
RegisterLogin

ART812

CAT: 0804-HY-139289-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-139289-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ART812 is an orally active DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. ART812 has an IC50 value of 240 nM for cell based microhomology-mediated end joining (MMEJ) [1][2].
CAS Number
2607138-82-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/art812.html
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H]([C@H](O)[C@@H]1O)N(C2=NC(C)=CC(C(F)(F)F)=C2)C1=O)N(C3=CC=C(F)C(Cl)=C3)C
Molecular Formula
C19H16ClF4N3O4
Molecular Weight
461.79
Precautions
H302, H315, H319
References & Citations
[1]Zatreanu D, et al. Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance. Nat Commun. 2021 Jun 17;12 (1) :3636.|[2]Peter BLENCOWE, et al. Preparation of heterocyclic compounds for use in the treatment of cancer. WO2021028643 A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-145056-01ART615
HY-139289S-01ART899
HY-148710ARTD10/PARP10-IN-2
HY-148709-01ARTD10/PARP10-IN-1
HY-P76734-01ART1, Cynomolgus (HEK293, His)
HY-RS01044ART1 Human Pre-designed siRNA Set A
HY-RS18463Art1 Mouse Pre-designed siRNA Set A
HY-RS24944Art1 Rat Pre-designed siRNA Set A

Alternative Products

CatalogName
M35191-01ART812

Popular Products