3,3'-Difluorobenzaldazine

3,3'-Difluorobenzaldazine

• CAS Number: 15332-10-2
• UNSPSC Description: 3,3'-Difluorobenzaldazine (DFB) is a selective positive allosteric modulator of mGluR5. 3,3'-Difluorobenzaldazine potentiates 3- to 6-fold action for mGlu5 agonists (Glutamate, Quisqualate, and 3,5-Dihydroxyphenylglycine), with EC50s in the 2 to 5 μM range[1].
• Target Antigen: mGluR
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/3-3-difluorobenzaldazine.html
• Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: FC1=CC(/C=N/N=C/C2=CC=CC(F)=C2)=CC=C1
• Molecular Weight: 244.24
• References & Citations: [1]O'Brien JA, et al, Chen TB, et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003;64(3):731-740.|[2]Chan MH, et al. Attenuation of ketamine-evoked behavioral responses by mGluR5 positive modulators in mice. Psychopharmacology (Berl). 2008 May;198(1):141-8.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported