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EGFR-IN-128

CAT: 0804-HY-168151Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168151Size:1 Each
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Description
EGFR-IN-128 (compund 28) is a potent and selective molecule targeting wild-type EGFR Ex20Ins that demonstrates efficacy in multiple human xenograft models and can cross the blood-brain barrier in preclinical species[1].
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-128.html
Smiles
O=C(C=C)N(C1)CC2=C1N=C(N2C3=CC=NC=C3)C4=CC=CC(C#CC5=CC=CC=C5)=C4
Molecular Formula
C27H20N4O
Molecular Weight
416.47
References & Citations
[1]Thomson C, et al. Optimization of Potent, Efficacious, Selective and Blood-Brain Barrier Penetrating Inhibitors Targeting EGFR Exon20 Insertion Mutations. J Med Chem. 2024 Sep 28.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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