PD-1/PD-L1-IN-10

PD-1/PD-L1-IN-10

• CAS Number: 2487550-41-2
• UNSPSC Description: PD-1/PD-L1-IN-10 (compound B2) is an orally active PD-1/PD-L1 inhibitor (IC50 of 2.7 nM) with potent anticancer efficacy[1].
• Target Antigen: Apoptosis; PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Apoptosis;Immunology/Inflammation
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pd-1-pd-l1-in-10.html
• Purity: 99.61
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: CC1=C(C=CC=C1C2=CC=CC=C2)COC3=C(C=C(C(OCC4=CC(C#N)=CC=C4)=C3)CN[C@H](C(O)=O)C(O)C)[N+]([O-])=O
• Molecular Weight: 581.62
• References & Citations: [1]Yiqiang OuYang, et al. Design, Synthesis, and Evaluation of o-(Biphenyl-3-ylmethoxy)nitrophenyl Derivatives as PD-1/PD-L1 Inhibitors with Potent Anticancer Efficacy In Vivo. J Med Chem. 2021 May 26.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported