Amlodipine-d4

• Description :

  Amlodipine-d4 is a deuterium labeled Amlodipine (HY-B0317) . Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H315, H318, H373, H410

• Target :

  Calcium Channel; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling; Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Purity :

  98.46

• Solubility :

  DMSO : 31.25 mg/mL (ultrasonic; warming)

• Smiles :

  CCOC(C1=C(COC([2H])([2H])C([2H])([2H])N)NC(C)=C(C(OC)=O)C1C2=C(C=CC=C2)Cl)=O

• Molecular Formula :

  C20H21D4ClN2O5

• Molecular Weight :

  412.90

• Precautions :

  H301, H315, H318, H373, H410

• References & Citations :

  [1]Kishen G. Bulsara, et al. Amlodipine.|[2]Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50 (5) :896]. Drugs. 1995;50 (3) :560-586.|[3]Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492 (2-3) :103-12.|[4]Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41 (2) :80-87.|[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-246.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1185246-14-3]