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Amlodipine-d4

CAT: 0804-HY-B0317S1Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0317S1Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Amlodipine-d4 is a deuterium labeled Amlodipine. Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer[1][2][3].
CAS Number
1185246-14-3
UNSPSC
12352005
Hazard Statement
H301, H315, H318, H373, H410
Target
Calcium Channel; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.46
Solubility
DMSO : 31.25 mg/mL (ultrasonic; warming)
Smiles
CCOC(C1=C(COC([2H])([2H])C([2H])([2H])N)NC(C)=C(C(OC)=O)C1C2=C(C=CC=C2)Cl)=O
Molecular Formula
C20H21D4ClN2O5
Molecular Weight
412.90
Precautions
H301, H315, H318, H373, H410
References & Citations
[1]Kishen G. Bulsara, et al. Amlodipine.|[2]Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50 (5) :896]. Drugs. 1995;50 (3) :560-586.|[3]Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492 (2-3) :103-12.|[4]Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41 (2) :80-87.|[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-246.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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