Amlodipine

• Description:

  Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H318, H373, H410

• Target:

  Calcium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Amlodipine.html

• Purity:

  99.87

• Solubility:

  DMSO : 31.25 mg/mL (ultrasonic)

• Smiles:

  O=C (OCC) C1=C (NC (C) =C (C1C2=CC=CC=C2Cl) C (OC) =O) COCCN

• Molecular Formula:

  C20H25ClN2O5

• Molecular Weight:

  408.88

• Precautions:

  H301, H318, H373, H410

• References & Citations:

  [1]Kishen G. Bulsara, et al. Amlodipine.|[2]Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50 (5) :896]. Drugs. 1995;50 (3) :560-586.|[3]Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492 (2-3) :103-12.|[4]Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41 (2) :80-87.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  L-type calcium channel

• Citation 01:

  Biochem Biophys Res Commun. 2020 Feb 19;522 (4) :862-868.|Cells. 2022 Oct 8;11 (19) :3156.|Exp Mol Med. 2021 Apr;53 (4) :572-590.|Food Chem Toxicol. 2025 Feb 10:115317.|J Adv Res. 2024 Aug:62:187-198.|J Biochem Mol Toxicol. 2022 Oct 7; e23238.|J Chem Thermodyn. 2021, 106495.|medRxiv. 2025 May 21.|Nat Prod Commun. 2024 Mar 20.|SSRN. 2025 Nov 6.|Br J Pharmacol. 2022 May;179 (9) :2054-2077.|Dissolut Technol. 2021 Jun.|Sci Adv. 2025 Jan 24;11 (4) :eadp4765.

• CAS Number:

  88150-42-9