Amlodipine

CAT: 0804-HY-B0317-01Size: 500 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-B0317-01Size:500 mg

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Description

Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer[1][2][3].

CAS Number

88150-42-9

UNSPSC

12352005

Hazard Statement

H301, H318, H373, H410

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Amlodipine.html

Purity

99.87

Solubility

DMSO : 31.25 mg/mL (ultrasonic)

Smiles

O=C(OCC)C1=C(NC(C)=C(C1C2=CC=CC=C2Cl)C(OC)=O)COCCN

Molecular Formula

C20H25ClN2O5

Molecular Weight

408.88

Precautions

H301, H318, H373, H410

References & Citations

[1]Kishen G. Bulsara, et al. Amlodipine.|[2]Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50 (5) :896]. Drugs. 1995;50 (3) :560-586.|[3]Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492 (2-3) :103-12.|[4]Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41 (2) :80-87.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

L-type calcium channel

Citation 01

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Catalog	Name
AG203	Amlodipine

Amlodipine

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