Benzo[a]pyrene-d12

Benzo[a]pyrene-d12

• CAS Number: 63466-71-7
• UNSPSC Description: Benzo[a]pyrene-d12 is the deuterium labeled Benzo[a]pyrene[1]. Benzo[a]pyrene shows lung carcinogenicity in animal models, and it is frequently used in chemoprevention studies[2][3].
• Target Antigen: Endogenous Metabolite
• Type: Isotope-Labeled Compounds
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Solubility: 10 mM in DMSO
• Smiles: [2H]C1=C2C([2H])=C([2H])C([2H])=C3C([2H])=C([2H])C4=C([2H])C5=C([2H])C([2H])=C([2H])C([2H])=C5C(C4=C32)=C1[2H]
• Molecular Weight: 264.38
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Saeko Onami, et al. Dosimetry for lung tumorigenesis induced by urethane, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice. J Toxicol Pathol. 2017 Jul; 30(3): 209–216.|[3]Yeo CD, et al. Roflumilast treatment inhibits lung carcinogenesis in benzo(a)pyrene-induced murine lung cancer model. Eur J Pharmacol. 2017 Oct 5812:189
• Shipping Conditions: Room temperature
• Storage Conditions: Store at room temperature 3 years
• Clinical Information: No Development Reported