Benzo[a]pyrene

• Description:

  Benzo[a]pyrene shows lung carcinogenicity in animal models, and it is frequently used in chemoprevention studies.

• Product Name Alternative:

  3,4-Benzopyrene

• UNSPSC:

  12352005

• Hazard Statement:

  H316, H317, H340, H350, H360, H400, H410

• Target:

  Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Benzo-a-pyrene.html

• Purity:

  99.97

• Solubility:

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  C12=C(C=C3)C=C(C=CC=C4)C4=C1C=CC5=CC=CC3=C25

• Molecular Formula:

  C20H12

• Molecular Weight:

  252.31

• Precautions:

  H316, H317, H340, H350, H360, H400, H410

• References & Citations:

  [1]Saeko Onami, et al. Dosimetry for lung tumorigenesis induced by urethane, 4- (N-methyl-N-nitrosamino) -1- (3-pyridyl) -1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice. J Toxicol Pathol. 2017 Jul; 30 (3) : 209–216.|[2]Yeo CD, et al. Roflumilast treatment inhibits lung carcinogenesis in benzo (a) pyrene-induced murine lung cancer model. Eur J Pharmacol. 2017 Oct 5;812:189-|[3]Foth H, et al. Pharmacokinetics of low doses of benzo [a] pyrene in the rat[J]. Food and chemical toxicology, 1988, 26 (1) : 45-51.|[4]Anandakumar P, et al. Capsaicin inhibits benzo (a) pyrene-induced lung carcinogenesis in an in vivo mouse model. Inflamm Res. 2012 Nov;61 (11) :1169-75.|[5]Kasala ER, et al. Benzo (a) pyrene induced lung cancer: Role of dietary phytochemicals in chemoprevention. Pharmacol Rep. 2015 Oct;67 (5) :996-1009.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature 3 years

• Scientific Category:

  Natural Products

• Clinical Information:

  Phase 1

• CAS Number:

  [50-32-8]