DOTAGA-anhydride

• Description :

  DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs) . DOTAGA-anhydride has been successfully used for labeling antibodies (e.g., Trastuzumab (HY-P9907) ) . DOTAGA-anhydride can be used for the synthesis of a bimodal tag for Single-photon emission computed tomography (SPECT) or PET/optical imaging[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319

• Target :

  Biochemical Assay Reagents; Radionuclide-Drug Conjugates (RDCs)

• Type :

  Reference compound

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/dotaga-anhydride.html

• Purity :

  99.80

• Solubility :

  DMSO : 70 mg/mL (ultrasonic)

• Smiles :

  O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(C(CCC(O2)=O)C2=O)CC1

• Molecular Formula :

  C19H30N4O9

• Molecular Weight :

  458.46

• Precautions :

  H315, H319

• References & Citations :

  [1]Bernhard C, et al. DOTAGA-anhydride: a valuable building block for the preparation of DOTA-like chelating agents. Chemistry. 2012 Jun 18;18 (25) :7834-41.

• Shipping Conditions :

  Dry Ice

• Storage Conditions :

  -80°C, stored under nitrogen

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  RDC Bifunctional Chelator

• CAS Number :

  [1375475-53-8]