DOTAGA-anhydride

CAT: 0804-HY-W087187-01Size: 5 mgDry Ice: YesHazardous: No
CAT#:0804-HY-W087187-01Size:5 mg
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Description
DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs) . DOTAGA-anhydride has been successfully used for labeling antibodies (e.g., Trastuzumab (HY-P9907) ) . DOTAGA-anhydride can be used for the synthesis of a bimodal tag for Single-photon emission computed tomography (SPECT) or PET/optical imaging[1].
CAS Number
[1375475-53-8]
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Biochemical Assay Reagents; Radionuclide-Drug Conjugates (RDCs)
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/dotaga-anhydride.html
Purity
99.80
Solubility
DMSO : 70 mg/mL (ultrasonic)
Smiles
O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(C(CCC(O2)=O)C2=O)CC1
Molecular Formula
C19H30N4O9
Molecular Weight
458.46
Precautions
H315, H319
References & Citations
[1]Bernhard C, et al. DOTAGA-anhydride: a valuable building block for the preparation of DOTA-like chelating agents. Chemistry. 2012 Jun 18;18 (25) :7834-41.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, stored under nitrogen
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RDC Bifunctional Chelator

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