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Pancuronium (dibromide) (Standard)

CAT: 0804-HY-B0429R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0429R-01Size:5 mg
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Description
Pancuronium (dibromide) (Standard) is the analytical standard of Pancuronium (dibromide) . This product is intended for research and analytical applications. Pancuronium dibromide, a bis-quaternary steroid, is a neuromuscular relaxant. Pancuronium dibromide inhibits neuromuscular transmission by competing with acetylcholine for binding sites on nACh receptors. Pancuronium dibromide also inhibits cardiac muscarinic receptors and has a sympathomimetic action[1][2][3].
CAS Number
15500-66-0
UNSPSC
12352005
Target
NAChR; Reference Standards
Type
Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pancuronium-dibromide-standard.html
Smiles
C[N+]1([C@@H]2[C@@H](OC(C)=O)C[C@@](CC[C@]3([H])[C@]4([H])CC[C@@]5(C)[C@@]3([H])C[C@H]([N+]6(C)CCCCC6)[C@@H]5OC(C)=O)([H])[C@]4(C)C2)CCCCC1.[Br-].[Br-]
Molecular Formula
C35H60Br2N2O4
Molecular Weight
732.67
References & Citations
[1]A D Fryer, et al. Pancuronium and gallamine are antagonists for pre- and post-junctional muscarinic receptors in the guinea-pig lung. Naunyn Schmiedebergs Arch Pharmacol. 1987 Apr;335 (4) :367-71.|[2]E Maestrone, et al. Extracellular pancuronium affects sodium current in chick embryo sensory neurons. Br J Pharmacol. 1994 Jan;111 (1) :283-7.|[3]J R Docherty, et al. A comparison of the effects of pancuronium bromide and its monoquaternary analogue, ORG NC 45, on autonomic and somatic neurotransmission in the rat. Br J Pharmacol. 1980;71 (1) :225-33.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
Launched

Chemical Information

Pancuronium Bromide

Pancuronium bromide is a bromide salt consisting of two bromide ions and one pancuronium dication. It has a role as a cholinergic antagonist, a nicotinic antagonist and a muscle relaxant. It contains a pancuronium.

CAS Number15500-66-0
PubChem CID27350
IUPAC Name[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate dibromide
Molecular FormulaC35H60Br2N2O4
Molecular Weight732.7
Topological Polar Surface Area52.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count43
Formal Charge0
Complexity1000
SMILES
CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@@H]([C@]2(C[C@@H]1[N+]4(CCCCC4)C)C)CC[C@]5([C@H]3C[C@@H]([C@@H]5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-].[Br-]
InChI
InChI=1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1
InChIKey
NPIJXCQZLFKBMV-YTGGZNJNSA-L
Chemical Structure
2D Structure
2D structure of Pancuronium Bromide
CAS: 15500-66-0
CID: 27350
Formula: C35H60Br2N2O4
MW: 732.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight732.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass732.28993
Monoisotopic Mass730.29198
Topological Polar Surface Area52.6 Ų
Heavy Atom Count43
Formal Charge0
Complexity1000
Isotope Atom Count0
Defined Atom Stereocenter Count10
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
B1612-SPancuronium dibromide
AR-D06268-01Dacuronium Dibromide (Pancuronium Bromide EP Impurity A, Pancuronium Bromide USP Related Compound C)
AR-D06272-01Pancuronium Bromide (Vecuronium Bromide EP Impurity B Dibromide)
217622Pancuronium Dibromide (1,1'- (3alpha,17beta-Dihydroxy-2alpha,5beta-androstan-2-beta,16beta-ylene) bis[1-methylpiperidinium] Diacetate Dibromide, Nicotinic Acetylchorine Receptor Antagonist, Pancuronium Dibromide, nAChR Antagonist, Pancuronium Dibromide) discontinued. see 462012

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