KX2-361

• Description:

  KX2-361 (KX-02) is a Src-kinase and tubulin polymerization inhibitor. KX2-361 shows good oral bioavailability and readily crosses the BBB in mice. KX2-361 shows anti-tumor activity and induces apoptosis of Glioblastoma (GBM) cell[1].

• Product Name Alternative:

  KX-02

• UNSPSC:

  12352005

• Target:

  Apoptosis; Microtubule/Tubulin; Src

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/kx2-361.html

• Purity:

  99.55

• Solubility:

  DMSO : 10.71 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C (NCC1=CC=CC (F) =C1) CC2=NC=C (C3=CC=C (N4CCOCC4) C=C3) C=C2

• Molecular Formula:

  C24H24FN3O2

• Molecular Weight:

  405.46

• References & Citations:

  [1]Ciesielski MJ, et al. KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma. J Neurooncol. 2018 Dec;140 (3) :519-527.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  897016-26-1