KX2-361
CAT:
804-HY-111187-01
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
KX2-361
- CAS Number: 897016-26-1
- UNSPSC Description: KX2-361 (KX-02) is a Src-kinase and tubulin polymerization inhibitor. KX2-361 shows good oral bioavailability and readily crosses the BBB in mice. KX2-361 shows anti-tumor activity and induces apoptosis of Glioblastoma (GBM) cell[1].
- Target Antigen: Apoptosis; Microtubule/Tubulin; Src
- Type: Reference compound
- Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton;Protein Tyrosine Kinase/RTK
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/kx2-361.html
- Purity: 99.55
- Solubility: DMSO : 10.71 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: O=C(NCC1=CC=CC(F)=C1)CC2=NC=C(C3=CC=C(N4CCOCC4)C=C3)C=C2
- Molecular Weight: 405.46
- References & Citations: [1]Ciesielski MJ, et al. KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma. J Neurooncol. 2018 Dec;140(3):519-527.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, protect from light)
- Clinical Information: Phase 1