KX2-361

• Description :

  KX2-361 (KX-02) is a Src-kinase and tubulin polymerization inhibitor. KX2-361 shows good oral bioavailability and readily crosses the BBB in mice. KX2-361 shows anti-tumor activity and induces apoptosis of Glioblastoma (GBM) cell[1].

• Product Name Alternative :

  KX-02

• UNSPSC :

  12352005

• Target :

  Apoptosis; Microtubule/Tubulin; Src

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/kx2-361.html

• Purity :

  99.55

• Solubility :

  DMSO : 10.71 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(NCC1=CC=CC(F)=C1)CC2=NC=C(C3=CC=C(N4CCOCC4)C=C3)C=C2

• Molecular Formula :

  C24H24FN3O2

• Molecular Weight :

  405.46

• References & Citations :

  [1]Ciesielski MJ, et al. KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma. J Neurooncol. 2018 Dec;140 (3) :519-527.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [897016-26-1]