PIN1 inhibitor API-1

PIN1 inhibitor API-1

• Alternative Name: Erythromycin Cyclocarbonate
• CAS Number: 680622-70-2
• UNSPSC Description: PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC50 of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development[1].
• Target Antigen: MicroRNA
• Type: Reference compound
• Related Pathways: Epigenetics
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pin1-inhibitor-api-1.html
• Purity: 98.54
• Solubility: DMSO : 250 mg/mL (ultrasonic)
• Smiles: O=C(NCC1=CC=C(COC2=C3NC=NC3=NC(N)=N2)C=C1)C(F)(F)F
• Molecular Weight: 366.30
• References & Citations: [1]Pu W, et al. Targeting Pin1 by inhibitor API-1 regulates microRNA biogenesis and suppresses hepatocellularcarcinoma development. Hepatology. 2018 Aug;68(2):547-560.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported