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Satigrel

CAT: 0804-HY-114564-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114564-02Size:10 mg
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Description
Satigrel (E5510) is a potent inhibitor of platelet aggregation. Satigrel inhibits collagen- and arachidonic acid-induced platelet aggregation through preventing thromboxane A2 synthesis by selective inhibition of the target enzyme, PGHS1, which exists in platelets. Satigrel inhibits PGHS1 (IC50: 0.081 μM) and PGHS2 (IC50: 5.9 μM) . Satigrel is against Type III PDE, Type V and Type II (IC50: 15.7 μM, 39.8 μM and 62.4 μM, respectively) [1].
CAS Number
111753-73-2
Product Name Alternative
E5510
UNSPSC
12352005
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/satigrel.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CC/C(C#N)=C(C1=CC=C(C=C1)OC)/C2=CC=C(C=C2)OC)O
Molecular Formula
C20H19NO4
Molecular Weight
337.37
References & Citations
[1]N Nagakura, et al. Mechanisms of satigrel (E5510), a new anti-platelet drug, in inhibiting human platelet aggregation. Selectivity and potency against prostaglandin H synthases isozyme activities and phosphodiesterase isoform activities. Biol Pharm Bull. 1996 Jun;19 (6) :828-33.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Satigrel

Satigrel is a small molecule drug. Satigrel has a monoisotopic molecular weight of 337.13 Da.

CAS Number111753-73-2
PubChem CID65913
IUPAC Name4-cyano-5,5-bis(4-methoxyphenyl)pent-4-enoic acid
Molecular FormulaC20H19NO4
Molecular Weight337.4
XLogP3.7
Topological Polar Surface Area79.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count25
Formal Charge0
Complexity491
SMILES
COC1=CC=C(C=C1)C(=C(CCC(=O)O)C#N)C2=CC=C(C=C2)OC
InChI
InChI=1S/C20H19NO4/c1-24-17-8-3-14(4-9-17)20(16(13-21)7-12-19(22)23)15-5-10-18(25-2)11-6-15/h3-6,8-11H,7,12H2,1-2H3,(H,22,23)
InChIKey
GRVCTHTXJDYIHB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Satigrel
CAS: 111753-73-2
CID: 65913
Formula: C20H19NO4
MW: 337.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight337.4
XLogP33.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass337.13140809
Monoisotopic Mass337.13140809
Topological Polar Surface Area79.6 Ų
Heavy Atom Count25
Formal Charge0
Complexity491
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA5728-25Satigrel

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