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Citraconic anhydride

CAT: 0804-HY-78035-01Size: 10 gDry Ice: NoHazardous: No
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CAT#:0804-HY-78035-01Size:10 g
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Description
Citraconic anhydride (Methylmaleic anhydride) is a derivative of maleic anhydride and novel antigen retrieval solution. Citraconic anhydride reversibly blocks protein amino groups, stabilizing specific enzymes and improving their catalytic performance. Citraconic anhydride reacts with free amino groups on proteins (especially lysine residues), converting positively charged NH3+ into carboxyl groups, thereby disrupting methylene bridge crosslinks caused by Formaldehyde during antigen retrieval. Citraconic anhydride functionalizes Isotactic polypropylene. Citraconic anhydride precisely responds to pH changes to achieve reversible modification. Citraconic anhydride is irritating to skin and eyes[1][2][3][4][5].
CAS Number
616-02-4
Product Name Alternative
Methylmaleic anhydride
UNSPSC
12352200
Hazard Statement
H314, H317, H334
Target
Biochemical Assay Reagents
Type
Biochemical Assay Reagents
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/citraconic-anhydride.html
Purity
99.81
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1OC(C(C)=C1)=O
Molecular Formula
C5H4O3
Molecular Weight
112.08
Precautions
H314, H317, H334
References & Citations
[1]Hermanson G T. Chapter 2-functional targets for bioconjugation[J]. Bioconjugate Techniques, 2013, 3: 127-228.|[2]Devrim Y G, et al. Functionalization of isotactic polypropylene with citraconic anhydride. Polymer Bulletin, 2007, 59 (4) : 447-456.|[3]Yankeelov JA Jr, et al. Methylmaleic anhydride as a reversible blocking agent during specific arginine modification. Biochem Biophys Res Commun. 1971 Mar 5;42 (5) :886-91. |[4]Melodia D, et al. Traceless pH-Sensitive Antibody Conjugation Inspired by Citraconic Anhydride. Biomacromolecules. 2022 Dec 12;23 (12) :5322-5329. |[5]Leong AS, et al. Citraconic anhydride: a new antigen retrieval solution. Pathology. 2010 Jan;42 (1) :77-81.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

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