EML 425

• Description :

  EML425 is a potent and selective CREB binding protein (CBP) /p300 inhibitor with IC50s of 2.9 and 1.1 μM, respectively.

• UNSPSC :

  12352005

• Target :

  Epigenetic Reader Domain; Histone Acetyltransferase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Metabolic Disease; Neurological Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/EML_425.html

• Concentration :

  10mM

• Purity :

  98.04

• Solubility :

  DMSO : ≥ 250 mg/mL

• Smiles :

  O=C(N(C(N(CC1=CC=CC=C1)C/2=O)=O)CC3=CC=CC=C3)C2=C/C4=C(C=C(O)C=C4C)C

• Molecular Formula :

  C27H24N2O4

• Molecular Weight :

  440.49

• References & Citations :

  [1]Milite C, et al. A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach. J Med Chem. 2015 Mar 26;58 (6) :2779-98.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CBP/p300; TIP60

• CAS Number :

  [1675821-32-5]