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Mouse anti Human alpha SNAP

CAT: 0579-X1026Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0579-X1026Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SNAPs (soluble NSF attachment proteins), acting in concert with SNAREs (SNAP receptors) and the N-ethylmaleimide-sensitive fusion protein (NSF), are required for the fusion of transport vesicles to their target membranes in synaptic transmission, intra-Golgi transport, endosome-to-endosome fusion and transcytotic vesicles-to-plasma membrane transport. Vesicle-to-target membrane docking (initial contact) occurs when the vesicle SNARE binds to its cognate target membrane SNARE. Beta-SNAP (or SNAP in brain) then binds to this docking complex and mediates the binding of NSF and thus the formation of a 20 S fusion particle. It is thought that, once NSF is bound, ATP hydrolysis by NSF initiates the fusion process. Whereas alpha-SNAP is expressed in all mammalian tissues, beta-SNAP is expressed only in brain.
CAS Number
9007-83-4
Synonyms
alpha/beta SNAP, Mouse Anti alpha soluble NSF attachment Protein,SNAPA
UniProt
P54920 (Human)
Host
Mouse
Species Reactivity
Human, Rat, Bovine
Isotype
IgG1
Clone
15D4
Conjugation
Unconjugated
Type
Monoclonal Antibody
Source
Monoclonal antibody 15D4 obtained immunization of Balb/C mice with recombinant Human alpha -SNAP
Applications
WB, IP, Enzyme Immunoassay
Field of Research
Signal Transduction
Purification Method
The antibody was purified to >95% homogeneity by standard chromatographic techniques
Assay Principle
Optimal concentration should be evaluated by serial dilutions. Clone 4E4 anti-?SNAP specifically recognizes ?-SNAP as a single band of ~36 kDa on western blot of rat kidney, rat brain and MDBK cells and does not recognize ?-SNAP Application: A dilution of 0.5-5 µg/mL is sµggested for western blot and 2-10 µg/mL for immunoprecipitation.
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
100 µg monoclonal antibody in 0,02 M sodium phosphate, pH 7,5, 0,15 M sodium chloride, 50% glycerol; No preservatives have been added.
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
Shipping Conditions
Room Temperature
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
WB

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