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YHO-13177

CAT: 0804-HY-12757-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12757-01Size:5 mg
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Description
YHO-13177, a acrylonitrile derivative, is an orally active, potent and specific inhibitor of breast cancer resistance protein (BCRP) and ABCG2 with an IC50 value of 10 nM. YHO-13177 potentiates the cytotoxicity of SN-38 in HCT116 and A549 cells that express BCRP. YHO-13177 combined with Irinotecan significantly suppresses the tumor growth in an HCT116/BCRP xenograft model[1][2][3].
CAS Number
912287-56-0
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
BCRP
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/YHO-13177.html
Purity
99.65
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
N#C/C(C1=CC=C(OC)C(OC)=C1)=C\C2=CC=C(N3CCC(O)CC3)S2
Molecular Formula
C20H22N2O3S
Molecular Weight
370.47
Precautions
H302, H312, H332
References & Citations
[1]Yamazaki R, et al. Novel acrylonitrile derivatives, YHO-13177 and YHO-13351, reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo. Mol Cancer Ther. 2011 Jul;10 (7) :1252-63.|[2]Shishido Y, et al. ABCG2 inhibitor YHO-13351 sensitizes cancer stem/initiating-like side population cells to irinotecan. Anticancer Res. 2013 Apr;33 (4) :1379-86. |[3]Yu S, et al. The mechanisms of multidrug resistance of breast cancer and research progress on related reversal agents. Bioorg Med Chem. 2023 Nov 15;95:117486.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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