10,11-Dehydrocurvularin

• UNSPSC Description:

  10,11-Dehydrocurvularin is a prevalent fungal phytotoxin and an antibiotic. 10,11-Dehydrocurvularin is a strong activator of the heat shock response. 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity[1][2].

• Target Antigen:

  Antibiotic; HSP; TGF-beta/Smad

• Type:

  Natural Products

• Related Pathways:

  Anti-infection;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Stem Cell/Wnt;TGF-beta/Smad

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/10-11-dehydrocurvularin-1.html

• Purity:

  99.75

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=C(C(/C=C/CCC[C@@H]2C)=O)C(CC(O2)=O)=CC(O)=C1

• Molecular Weight:

  290.31

• References & Citations:

  [1]Xu Y, et al. Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus. Appl Environ Microbiol. 2013 Mar;79(6):2038-47.|[2]Cochrane RV, et al. Comparison of 10,11-Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs. Chembiochem. 2015 Nov;16(17):2479-83.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  21178-57-4