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5-Fluorouridine

CAT: 0804-HY-107856-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107856-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5-Fluorouridine, a metabolite of5-Fluorouracil , is a potent ribozyme self-cleavage inhibitor. 5-Fluorouridine incorporates into both total and poly A RNA and has antiproliferative activity. 5-Fluorouridine induces apoptosis[1][2][3].
CAS Number
316-46-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; DNA/RNA Synthesis; Drug Metabolite
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5-fluorouridine.html
Concentration
10mM
Purity
99.97
Solubility
DMSO : ≥ 100 mg/mL|H2O : 100 mg/mL (ultrasonic)
Smiles
OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(C(F)=C2)=O)=O)O1
Molecular Formula
C9H11FN2O6
Molecular Weight
262.19
Precautions
H302, H315, H319, H335
References & Citations
[1]Wu FL, et, al. Gelatinases-stimuli nanoparticles encapsulating 5-fluorouridine and 5-aza-2'-deoxycytidine enhance the sensitivity of gastric cancer cells to chemical therapeutics. Cancer Lett. 2015 Jul 10;363 (1) :7-16.|[2]Schmittgen TD, et, al. Diverse gene expression pattern during 5-fluorouridine-induced apoptosis. Int J Oncol. 2005 Aug;27 (2) :297-306. |[3]Houghton JA, et, al. Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine. Cancer Res. 1979 Jul;39 (7 Pt 1) :2406-13.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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