Etoposide-d3

• Description :

  Etoposide-d3 (VP-16-d3) is the deuterium labeled Etoposide (HY-13629) . Etoposide (VP-16) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy[1].

• Product Name Alternative :

  VP-16-d3; VP-16-213-d3

• UNSPSC :

  12352005

• Target :

  Antibiotic; Apoptosis; Autophagy; Bacterial; Isotope-Labeled Compounds; Mitophagy; Topoisomerase

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Others

• Field of Research :

  Cancer; Infection

• Smiles :

  C[C@@H]1OC[C@]2([H])[C@@]([C@H](O)[C@@H](O)[C@H](O[C@@H]3C(C=C(OCO4)C4=C5)=C5[C@@H](C6=CC(OC)=C(O)C(OC([2H])([2H])[2H])=C6)[C@]7([H])[C@]3([H])COC7=O)O2)([H])O1

• Molecular Formula :

  C29H29D3O13

• Molecular Weight :

  591.58

• References & Citations :

  [1]Hande KR, et al. The Importance of Drug Scheduling in Cancer Chemotherapy: Etoposide as an Example. Oncologist. 1996;1 (4) :234-239.|[2]Calvani M, det al. Etoposide-Anti-Human VEGF a new strategy against human melanoma cells expressing stem-like traits. Oncotarget. 2016 Jun 9. doi: 10.18632/oncotarget.9939.|[3]Fuchs, J., et al. Comparative activity of NSC 119875, NSC 109724, NSC 123127, NSC 241240, and etoposide in heterotransplanted hepatoblastoma. Cancer, 1998. 83 (11) : p. 2400-7.|[4]Lee KI, et al. Etoposide induces pancreatic β-cells cytotoxicity via the JNK/ERK/GSK-3 signaling-mediated mitochondria-dependent apoptosis pathway. Toxicol In Vitro. 2016 Jul 26. pii: S0887-2333 (16) 30147-3.|[5]Cui D, et al. FBXW7 Confers Radiation Survival by Targeting p53 for Degradation.Cell Rep. 2020 Jan 14;30 (2) :497-509.e4.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported