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OICR41114

CAT: 0804-HY-169389Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169389Size:1 Each
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Description
OICR41114 (PROTAC 4) is a WDR5-targeting PROTAC degrader. OICR41114 degrades endogenous WDR5 with an EC50 and Dmax values of 40 nM and 49%, respectively. OICR41114 degrades HiBiT-tagged WDR5 in a proteasome-dependent manner[1]. OICR41114 is composed of target protein ligand (red part) Dimethyl-F-OICR-9429-COOH , E3 ligase ligand (blue part) OICR-8268-acrylic acid (HY-169390) and PROTAC linker (black part) Amino-PEG9-amine (HY-140210). The conjugate of E3 ligase ligand and linker is OICR-8268-acrylic acid-amino-PEG9-amine (HY-169391).
UNSPSC
12352005
Target
PROTACs; WDR5
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/oicr41114.html
Smiles
O=C(/C=C/C1=C(C(C(N[C@H](C2=CC=C(C(Cl)=C2)F)CC(N)=O)=O)=CN1)C3=C(C=C(C=C3)Cl)F)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(C4=CC=C(C(C5=CC=C(C(NC(C6=CNC(C=C6C(F)(F)F)=O)=O)=C5)N7C[C@H](N([C@H](C7)C)C)C)=C4)F)=O
Molecular Formula
C70H83Cl2F6N9O15
Molecular Weight
1475.36
References & Citations
[1]Mabanglo MF, et al. Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity. Nat Commun. 2024 Nov 23;15 (1) :10165.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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