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OICR41114

CAT: 0931-T203318-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T203318-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
PROTACs, JAK
Related Pathways
Chromatin/Epigenetic, JAK/STAT signaling, Stem Cells, Angiogenesis, PROTAC, Tyrosine Kinase/Adaptors
Bioactivity
OICR41114 (PROTAC4) is a PROTAC degrader targeting WDR5. It effectively degrades endogenous WDR5 with an EC50 of 40 nM and a Dmax of 49%. The degradation of HiBiT-tagged WDR5 by OICR41114 occurs in a proteasome-dependent manner. This compound is composed of a target protein ligand, Dimethyl-F-OICR-9429-COOH, an E3 ligase ligand, OICR-8268-acrylic acid, and a PROTAC linker, Amino-PEG9-amine. Notably, the conjugate of the E3 ligase ligand and the linker is OICR-8268-acrylic acid-amino-PEG9-amine.
Molecular Formula
C70H83Cl2F6N9O15
Molecular Weight
1475.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-169389OICR41114

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