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RAMB4

CAT: 0804-HY-W054146-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W054146-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RAMB4 is a ubiquitin-proteasome system (UPS) -stressor. RAMB4 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. RAMB4 triggers a ubiquitin-proteasome-system (UPS) -stress response without affecting 20S proteasome catalytic activities. Anticancer activity[1].
CAS Number
145888-79-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ptp1b-in-9.html
Purity
98.02
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
O=C(/C(CNC/1)=C/C2=CC=C(Cl)C(Cl)=C2)C1=C\C3=CC(Cl)=C(C=C3)Cl
Molecular Formula
C19H13Cl4NO
Molecular Weight
413.12
Precautions
H302, H315, H319, H335
References & Citations
[1]Anchoori RK, et al. Stressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cells.PLoS One. 2011;6 (8) :e23888.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

3,5-Bis(3,4-dichlorobenzylidene)piperidin-4-one
CAS Number145888-79-5
PubChem CID5388806
IUPAC Name(3E,5E)-3,5-bis[(3,4-dichlorophenyl)methylidene]piperidin-4-one
Molecular FormulaC19H13Cl4NO
Molecular Weight413.1
XLogP5.7
Topological Polar Surface Area29.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count25
Formal Charge0
Complexity516
SMILES
C\1NC/C(=C\C2=CC(=C(C=C2)Cl)Cl)/C(=O)/C1=C/C3=CC(=C(C=C3)Cl)Cl
InChI
InChI=1S/C19H13Cl4NO/c20-15-3-1-11(7-17(15)22)5-13-9-24-10-14(19(13)25)6-12-2-4-16(21)18(23)8-12/h1-8,24H,9-10H2/b13-5+,14-6+
InChIKey
GJPXGFGIFQWUOC-ACFHMISVSA-N
Chemical Structure
2D Structure
2D structure of 3,5-Bis(3,4-dichlorobenzylidene)piperidin-4-one
CAS: 145888-79-5
CID: 5388806
Formula: C19H13Cl4NO
MW: 413.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight413.1
XLogP35.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass412.972175
Monoisotopic Mass410.975125
Topological Polar Surface Area29.1 Ų
Heavy Atom Count25
Formal Charge0
Complexity516
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T12579-01RAMB4
T12578-01(E, E) -RAMB4
MBS5767403(E,E)-RAMB4
M33081-01E, E-RAMB4

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