RAMB4

• Description :

  RAMB4 is a ubiquitin-proteasome system (UPS) -stressor. RAMB4 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. RAMB4 triggers a ubiquitin-proteasome-system (UPS) -stress response without affecting 20S proteasome catalytic activities. Anticancer activity[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Proteasome

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ptp1b-in-9.html

• Purity :

  98.02

• Solubility :

  DMSO : 5 mg/mL (ultrasonic)

• Smiles :

  O=C(/C(CNC/1)=C/C2=CC=C(Cl)C(Cl)=C2)C1=C\C3=CC(Cl)=C(C=C3)Cl

• Molecular Formula :

  C19H13Cl4NO

• Molecular Weight :

  413.12

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Anchoori RK, et al. Stressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cells.PLoS One. 2011;6 (8) :e23888.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [145888-79-5]