RAMB4

CAT: 0804-HY-W054146-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W054146-01Size:5 mg
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Description
RAMB4 is a ubiquitin-proteasome system (UPS) -stressor. RAMB4 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. RAMB4 triggers a ubiquitin-proteasome-system (UPS) -stress response without affecting 20S proteasome catalytic activities. Anticancer activity[1].
CAS Number
[145888-79-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ptp1b-in-9.html
Purity
98.02
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
O=C(/C(CNC/1)=C/C2=CC=C(Cl)C(Cl)=C2)C1=C\C3=CC(Cl)=C(C=C3)Cl
Molecular Formula
C19H13Cl4NO
Molecular Weight
413.12
Precautions
H302, H315, H319, H335
References & Citations
[1]Anchoori RK, et al. Stressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cells.PLoS One. 2011;6 (8) :e23888.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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