EAG1 Antibody / KCNH1

CAT: 0800-RQ7297Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0800-RQ7297Size:100 µg

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Description

Potassium voltage-gated channel subfamily H member 1, also called Ether-a-go-go potassium channel 1 (h-eag, EAG1) is a protein that in humans is encoded by the KCNH1 gene. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.

CAS Number

9007-83-4

Specifications

Western blot: 0.5-1 µg/mL

UniProt

O95259

Host

Rabbit

Reactivity

Human, Rat

Immunogen

Amino acids QDRSPILAEVKHSFYPC were used as the immunogen for the EAG1 antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

Purity

Antigen affinity purified

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2% Trehalose

Reconstitution

After reconstitution, the EAG1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This EAG1 antibody is available for research use only.

Storage Conditions

After reconstitution, the EAG1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

Optimal dilution of the EAG1 antibody should be determined by the researcher.

Image Legend

Western blot testing of 1) human U-87 MG, 2) human SH-SY5Y, 3) human HeLa, 4) human MCF7, 5) rat brain and 6) rat C6 cell lysate with EAG1 antibody. Predicted molecular weight ~111 kDa (may be observed larger than predicted due to glycosylation) .

UniProtKB · O95259

Voltage-gated delayed rectifier potassium channel KCNH1

KCNH1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: O95259
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: KCNH1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: B1AQ26, O76035, Q14CL3

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

Calmodulin-bindingIon channelPotassium channelVoltage-gated channel

Cellular component

Cell membraneCell projectionEndosomeMembraneNucleusPostsynaptic cell membraneSynapse

Disease

Disease variantEpilepsyIntellectual disability

PTM

GlycoproteinPhosphoprotein

Biological process

Ion transportPotassium transportTransport

Ligand

Lipid-bindingPotassium

Domain

TransmembraneTransmembrane helix

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Alternative Products

Catalog	Name
E55A14021	Human KCNH1/EAG1 Antibody
GTR18687557-01	KCNH1/EAG1 Mouse Monoclonal Antibody
RHB59301	Anti-Human KCNH1/EAG1 Antibody (SAA1808)
PTX24880-01	Anti-Human KCNH1/EAG1 Monoclonal Antibody (ABS2176)
AMRe87326-01	EAG1 Rabbit Monoclonal Antibody
MBS8594513-01	KCNH1 Antibody
APA1680-01	EAG1 Rabbit pAb