Ac-Nle-Pro-Nle-Asp-AMC

Ac-Nle-Pro-Nle-Asp-AMC

• CAS Number: 355140-49-7
• UNSPSC Description: Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis[1][2][3].
• Target Antigen: Proteasome
• Type: Peptides
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/ac-nle-pro-nle-asp-amc.html
• Purity: 99.85
• Solubility: DMSO : ≥ 100 mg/mL
• Smiles: CCCC[C@H](NC([C@@H]1CCCN1C([C@@H](NC(C)=O)CCCC)=O)=O)C(N[C@H](C(NC2=CC3=C(C(C)=CC(O3)=O)C=C2)=O)CC(O)=O)=O
• Molecular Weight: 655.74
• References & Citations: [1]Dunlop RA, et al. The impact of specific oxidized amino acids on protein turnover in J774 cells. Biochem J. 2008 Feb 15;410(1):131-40.|[2]Kirk-Ballard H, et al. An extract of Artemisia dracunculus L. inhibits ubiquitin-proteasome activity and preserves skeletal muscle mass in a murine model of diabetes. PLoS One. 2013;8(2):e57112.|[3]Pakavathkumar P, et al. Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine. Sci Rep. 2015 Sep 24;5:13730.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported