L-threo-3-Hydroxyaspartic acid
CAT:
804-HY-100801-01
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
L-threo-3-Hydroxyaspartic acid
- CAS Number: 7298-99-9
- UNSPSC Description: L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with Kis of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines[1].
- Target Antigen: EAAT
- Type: Reference compound
- Related Pathways: Membrane Transporter/Ion Channel
- Applications: Neuroscience-Neuromodulation
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/l-threo-3-hydroxyaspartic-acid.html
- Purity: 98.80
- Solubility: 10 mM in DMSO|1M NaOH : 14.91 mg/mL (ultrasonic;warming)
- Smiles: N[C@@H]([C@H](O)C(O)=O)C(O)=O
- Molecular Weight: 149.10
- References & Citations: [1]Hara R, et al Production of L-threo-3-Hydroxyaspartic Acid Using Asparaginase-Deficient Escherichia coli Expressing Asparagine Hydroxylase of Streptomyces coelicolor A3(2). Appl Environ Microbiol. 2015 Jun;81(11):3648-54|[2]Jensen AA, Bräuner-Osborne H. Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay. Biochem Pharmacol. 2004 Jun 1;67(11):2115-27.
- Shipping Conditions: Blue Ice
- Storage Conditions: -20°C, 3 years (Powder)
- Clinical Information: No Development Reported