L-threo-Sphingosine

• UNSPSC Description:

  L-threo-Sphingosine is a potent MAPK inhibitor. L-threo-Sphingosine induces apoptosis and clear DNA fragmentation. L-threo-Sphingosine shows anticancer effect[1].

• Target Antigen:

  Apoptosis; p38 MAPK

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/l-threo-sphingosine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCCCCCCCCCCCC/C=C/[C@H](O)[C@@H](N)CO

• Molecular Weight:

  299.49

• References & Citations:

  [1]Sakakura C, et al. Selectivity of sphingosine-induced apoptosis. Lack of activity of DL-erythyro-dihydrosphingosine. Biochem Biophys Res Commun. 1998 May 29;246(3):827-30.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  25695-95-8