Tyrosine kinase-IN-8

CAT:

804-HY-162489

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UNSPSC Description:
Tyrosine kinase-IN-8 (compound 4e) is a BCR‐ABL1 tyrosine kinase inhibitor (TKI). Tyrosine kinase-IN-8 shows anti-proliferative activity against K562 cells, a chronic myeloid leukemia (CML) cell line (CC50=0.8 µM). Tyrosine kinase-IN-8 can be used in the study of chronic leukemia[1].
Target Antigen:
Bcr-Abl
Type:
Reference compound
Related Pathways:
Protein Tyrosine Kinase/RTK
Applications:
Cancer-Kinase/protease
Field of Research:
Others
Assay Protocol:
https://www.medchemexpress.com/tyrosine-kinase-in-8.html
Solubility:
10 mM in DMSO
Smiles:
CC(C=CC(N1C(C2=CC=C(F)C=C2)=NOC13C(C=C(F)C=C4)=C4NC3=O)=C5)=C5NC6=NC(C7=CC=CN=C7)=CC=N6
Molecular Weight:
561.54
References & Citations:
[1]de Azevedo L D, et al. Spirooxadiazoline‐oxindoles derived from imatinib show antimyeloproliferative potential in K562 cells[J]. Archiv der Pharmazie, 2024: e2400029.
Shipping Conditions:
Room temperature
Clinical Information:
No Development Reported

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