Tyrosine kinase inhibitor

Tyrosine kinase inhibitor

• CAS Number: 1021950-26-4
• UNSPSC Description: Tyrosine kinase inhibitor is a potent tyrosine kinase inhibitor.
• Target Antigen: c-Met/HGFR
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/Tyrosine-kinase-inhibitor.html
• Purity: 99.88
• Solubility: DMSO : ≥ 46 mg/mL
• Smiles: O=C(NC1=CC=C(C=C1)F)C2(CC2)C(NC3=CC=C(C=C3)OC4=C5C(NC(C(NCCN6CCOCC6)=O)=C5)=NC=C4)=O
• Molecular Weight: 586.61
• References & Citations: [1]Inoue T, et al. 
 Two cases of gastrointestinal perforation after radiotherapy in patients receiving tyrosine kinase inhibitor for advanced renal cell carcinoma.
 World J Surg Oncol. 2012 Aug 20;10(1):167.|[2]Bowen JM, et al. 
 Development of a rat model of oral small molecule receptor tyrosine kinase inhibitor-induced diarrhea.
 Cancer Biol Ther. 2012 Nov 1;13(13).|[3]Sun FK, et al. 
 Multi-targeted tyrosine kinase inhibitor sunitinib: a novel strategy for sporadic malignant pheochromocytoma.
 Chin Med J (Engl). 2012 Jun;125(12):2231-4.|[4]Thamm DH.
 Tyrosine kinase inhibitor special issue.
 Vet Comp Oncol. 2012 Sep;10(3):161-2. doi: 10.1111/j.1476-5829.2012.00339.x.|[5]Eriksson A, et al. 
 The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia.
 Blood Cancer J. 2012 Aug 3;2:e81. doi: 10.1038/bcj.2012.28.|[6]Paul MK, et al. Tyrosine kinase - Role and significance in Cancer. Int J Med Sci. 2004;1(2):101-115.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported