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Edoxaban impurity 6

CAT: 0804-HY-134685-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-134685-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Edoxaban impurity 6 is an impurity of Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention[1][2].
CAS Number
480452-37-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Factor Xa; Thrombin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/edoxaban-impurity-6.html
Purity
98.30
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
ClC(C=N1)=CC=C1NC(C(N[C@@H]2[C@@H](C[C@H](CC2)C(N(C)C)=O)N)=O)=O
Molecular Formula
C16H22ClN5O3
Molecular Weight
367.83
Precautions
H302, H315, H319, H335
References & Citations
[1]Furugohri T, et al. DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost. 2008 Sep;6 (9) :1542-9.|[2]Mendell J, Lee F, Chen S, The Effects of the Antiplatelet Agents, Aspirin and Naproxen, on Pharmacokinetics and Pharmacodynamics of the Anticoagulant Edoxaban, a Direct Factor Xa Inhibitor. J Cardiovasc Pharmacol. 2013 Apr 23.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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