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ML395

CAT: 0804-HY-124305Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-124305Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ML395 is a potent and selective allosteric inhibitor of phospholipase D2 with antiviral activity. The cellular PLD1 IC50 value of ML395 exceeds 30,000 nM, while its cellular PLD2 IC50 value is 360 nM. ML395 shows excellent pharmacokinetic characteristics in vitro and physiochemical properties superior to other reported phospholipase inhibitors. ML395 shows interesting antiviral activity in cell-based assays against multiple influenza virus strains (H1, H3, H5, and H7) [1].
CAS Number
[1638957-17-1]
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ml395.html
Smiles
O=C(C1=CC=C2C=CC=CC2=C1)NCCN(CC3)CCC3(N(CC4=CC=CN=C4)CN5)C5=O
Molecular Formula
C26H29N5O2
Molecular Weight
443.54
References & Citations
[1]Discovery of a highly selective PLD2 inhibitor (ML395) : a new probe with improved physiochemical properties and broad-spectrum antiviral activity against influenza strains
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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