ML390 (Standard)

CAT: 0804-HY-100688RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-100688RSize:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
ML390 (Standard) is the analytical standard of ML390 (HY-100688) . This product is intended for research and analytical applications. ML390 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor. ML390 is an inducer of myeloid differentiation and causes myeloid differentiation in murine (ER-HoxA9) and human (U937 and THP1) acute myeloid leukemia (AML) models[1][2][3].
CAS Number
[2029049-79-2]
Target
Dihydroorotate Dehydrogenase; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=C(NCCC(N[C@H]1C(C=CC=C2)=C2CCC1)=O)C3=CC=C(OC(F)(F)F)C=C3
Molecular Formula
C21H21F3N2O3
Molecular Weight
406.40
References & Citations
[1]Sykes DB et al. Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia. National Center for Biotechnology Information (US) ; 2010-2013 Dec 15.|[2]David B Sykes, et al. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell. 2016 Sep 22;167 (1) :171-186.e15.|[3]Timothy A Lewis, et al. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett. 2016 Sep 28;7 (12) :1112-1117.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Related Products

CatalogName
HY-100688-01ML390
HY-N0423R-01Sophoricoside (Standard)
HY-N6670R-01Cefotetan (Standard)
HY-N0413RHupehenine (Standard)
HY-15743R-01Birabresib (Standard)
HY-100593RSpiramycin (Standard)
HY-10209R-01Masitinib (Standard)
HY-N0004R-01Oridonin (Standard)
HY-B0581R-01Dexrazoxane (Standard)
HY-14171R-01Bexarotene (Standard)

Alternative Products

CatalogName
B7824-5ML390
A13386-50ML390 50mg
A13386-10ML390 10mg
A13386-100ML390 100mg
A13386-5ML390 5mg
A13386-25ML390 25mg
A13386-10mM-DML390 10mM * 1mL in DMSO
abx098968-01Standard
ST-08004-02Ascorbic Acid Standard + Gallic Acid Standard + TROLOX Standard + BRS Electrolyte
ST-80004-01Ascorbic Acid Standard + Gallic Acid Standard + TROLOX Standard for biological samples

Popular Products