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1,2-Cyclohexanedione

CAT: 0804-HY-W007347-01Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W007347-01Size:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
1,2-Cyclohexanedione is an arginine modification reagent. 1,2-Cyclohexanedione interferes with the degradation of low-density lipoprotein by modifying the arginine group in apolipoprotein. 1,2-Cyclohexanedione can be used in the research of familial hypercholesterolemia[1][2][3].
CAS Number
765-87-7
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Biochemical Assay Reagents; LDLR
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/1-2-cyclohexanedione.html
Purity
99.24
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(CCCC1)=O
Molecular Formula
C6H8O2
Molecular Weight
112.13
Precautions
H302, H315, H319, H335
References & Citations
[1]Baker GF, et al. Glucose transport inhibitors protect against 1,2-cyclohexanedione-produced potassium loss from human red blood cells. Exp Physiol. 1998 Mar;83 (2) :239-42.|[2]Knight BL, et al. Degradation by cultured fibroblasts and macrophages of unmodified and 1,2-cyclohexanedione-modified low-density lipoprotein from normal and homozygous familial hypercholesterolaemic subjects. Biochem J. 1982 Jan 15;202 (1) :145-52. |[3]Lanza L, et al. Identification and Characterization of Thiamine Diphosphate-Dependent Lyases with an Unusual CDG Motif. Angew Chem Int Ed Engl. 2024 Aug 19;63 (34) :e202404045.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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