Azelastine-13C,d3

Azelastine-13C,d3

• UNSPSC Description: Azelastine-13C,d3 is deuterium labeled Azelastine. Azelastine, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2[1][2][3][4].
• Target Antigen: Histamine Receptor; Isotope-Labeled Compounds; SARS-CoV
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection;GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling;Others
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Infection; Endocrinology; Metabolic Disease; Inflammation/Immunology
• Solubility: 10 mM in DMSO
• Smiles: O=C1N(C2CCN([13C]([2H])([2H])[2H])CCC2)N=C(CC3=CC=C(Cl)C=C3)C4=C1C=CC=C4
• Molecular Weight: 385.91
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Carlos D. Zappia, et al. Azelastine potentiates antiasthmatic dexamethasone effect on a murine asthma model. Pharmacol Res Perspect. 2019 Dec; 7(6): e00531.|[3]Craig La Force. Review of the pharmacology, clinical efficacy, and safety of azelastine hydrochloridel. Expert Rev Clin Immunol. 2005 Jul;1(2):191-201.|[4]Li Yang, et al. Identification of SARS-CoV-2 entry inhibitors among already approved drugs. Acta Pharmacol Sin. 2020 Oct 28 : 1-7.|[5]Mohamed M Elseweidy, et al. Azelastine a potent antihistamine agent, as hypolipidemic and modulator for aortic calcification in diabetic hyperlipidemic rats model. Arch Physiol Biochem. 2020 Jul 2;1-8.|[6]Shao-Cheng Liu, et al. Effect of budesonide and azelastine on histamine signaling regulation in human nasal epithelial cells. Eur Arch Otorhinolaryngol. 2017 Feb;274(2):845-853.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported