Tubercidin

CAT: 0804-HY-100126-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100126-01Size:5 mg
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Description
Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC50 of 0.02 μM[1]. Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis[2]. Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP[1]. Tubercidin has antiviral activity[2].
CAS Number
[69-33-0]
Product Name Alternative
7-Deazaadenosine
UNSPSC
12352005
Hazard Statement
H300
Target
Antibiotic; Bacterial; DNA/RNA Synthesis; Influenza Virus
Type
Natural Products
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Tubercidin.html
Concentration
10mM
Purity
99.24
Solubility
DMSO : ≥ 30 mg/mL
Smiles
O[C@H]1[C@@H](O)[C@H](N2C=CC3=C2N=CN=C3N)O[C@@H]1CO
Molecular Formula
C11H14N4O4
Molecular Weight
266.26
Precautions
H300
References & Citations
[1]Bloch A, et al. On the mode of action of 7-deaza-adenosine (Tubercidin) . Biochim Biophys Acta. 1967 Mar 29;138 (1) :10-25.|[2]Kouni MH, et al. Prevention of tubercidin host toxicity by nitrobenzylthioinosine 5'-monophosphate for the treatment of schistosomiasis. Antimicrob Agents Chemother. 1989 Jun;33 (6) :824-7.|[3]Bergstrom DE, et al. Antiviral activity of C-5 substituted tubercidin analogues. J Med Chem. 1984 Mar;27 (3) :285-92.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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