Anti-Hu NKp80 APC

• Description:

  NKp80, also known as CLEC5C or KLRF1, is a type II transmembrane glycoprotein of the C lectin family, which is expressed in 80 kDa homodimers on NK cells, and subsets of CD8+ alpha/beta T cells, and gamma/delta T cells. It belongs to the activating coreceptors, which induce cytotoxicity, and production of pro-inflammatory cytokines. Its ligand AICL is expressed on myeloid cells.

• Certification:

  RUO

• Negative Species:

  Mouse, Rat

• Immunogen:

  Recombinant human NKp80 extracellular domain

• Target Antigen:

  NKp80

• Clone:

  5D12

• Applications:

  FC (QC tested)

• Format:

  APC

• Buffer:

  Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

• References & Citations:

  *Dennehy KM, Klimosch SN, Steinle A: Cutting edge: NKp80 uses an atypical hemi-ITAM to trigger NK cytotoxicity. J Immunol. 2011 Jan 15;186 (2) :657-61., URL: https://pubmed.ncbi.nlm.nih.gov/21149606/, *Campbell TM, McSharry BP, Steain M, Russell TA, Tscharke DC, Kennedy JJ, Slobedman B, Abendroth A: Functional paralysis of human natural killer cells by alphaherpesviruses. PLoS Pathog. 2019 Jun 13;15 (6) :e1007784, URL: https://pubmed.ncbi.nlm.nih.gov/31194857/, *Rückrich T, Steinle A: Attenuated natural killer (NK) cell activation through C-type lectin-like receptor NKp80 is due to an anomalous hemi-immunoreceptor tyrosine-based activation motif (HemITAM) with impaired Syk kinase recruitment capacity. J Biol Chem. 2013 Jun 14;288 (24) :17725-33., URL: https://pubmed.ncbi.nlm.nih.gov/23609447/

• Storage Conditions:

  Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

• Specificity:

  The mouse monoclonal antibody 5D12 recognizes an extracellular epitope of human NKp80 (CLEC5C), a C-type lectin family member, expressed on NK cells and subsets of T cells.

• Applications Notes:

  6

• Species:

  Human, Monkey

• CAS Number:

  9007-83-4

• Isotype:

  Mouse IgG1 kappa